At the start of 2020, nobody could have foreseen that we would experience a global pandemic, which has fundamentally changed the world at a ferocious pace. Some 30 years after the Convention on the Rights of the Child was endorsed by almost all states, COVID-19 has put decades of progress for the world’s most vulnerable children at risk. We must now move quickly in 2021 to ensure these setbacks are not permanent for a generation of the world’s children.